WISP3 antibody (AA 1-50)

Catalog No. ABIN7227052

The Rabbit Polyclonal anti-WISP3 antibody (ABIN7227052) specifically detects WISP3 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for WISP3 antibody (AA 1-50) (ABIN7227052)

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WISP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-WISP3 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit Anti-WISP-3 Polyclonal Antibody

Specificity: The antibody detects endogenous WISP-3.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 1-50

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for WISP3

Target: WISP3 (Wnt1 Inducible Signaling Pathway Protein 3 (WISP3))

Alternative Name: WISP-3

Background: WNT1-inducible-signaling pathway protein 3, WISP-3, CCN family member 6WISP3 (WNT1 inducible signaling pathway protein 3) encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of WISP3 are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for WISP3.

Molecular Weight: 55kD

Gene ID: 8838

UniProt: O95389

Pathways: WNT Signaling, Growth Factor Binding