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Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 111-140), (N-Term) antibody

Details for Product No. ABIN390365, Supplier: Log in to see
Antigen
  • CG10523
  • Dmel\\CG10523
  • Dpark
  • SD01679
  • dpk
  • si:ch211-123f21.1
  • zgc:112390
  • LOC100150461
  • PRKN
  • Park
  • Prkn
  • AR-JP
  • LPRS2
  • PDJ
  • pdr-1
Epitope
AA 111-140, N-Term
24
24
23
18
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
176
47
38
8
6
2
2
2
2
1
1
Host
Rabbit
156
16
10
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
3
3
3
3
3
3
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
136
58
52
33
26
23
12
10
4
2
2
1
1
Supplier
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Immunogen This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 AA from the N-terminal region of human Parkin.
Clone RB7371
Isotype Ig
Specificity This Parkin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118~148 amino acids from the N-terminal region of human Park2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Parkin (PARK2 Antibody Abstract)
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known, however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function.
Synonyms: Parkin isoform 1, Parkin, E3 ubiquitin ligase, Ubiquitin E3 ligase PRKN, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PRKN, Park2
Molecular Weight 51651 DA
Gene ID 5071
NCBI Accession NP_004553
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Pathways
Application Notes WB = 1:1000, FACS = 1:10-50, IF = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) (AA 111-140), (N-Term) antibody (ABIN390365) Western blot analysis of anti-PARK2 (Parkin) Antibody (N-term) (ABIN390365) in NCI-H4...
Background publications Wang, Denison, Lai et al.: "Parkin gene alterations in hepatocellular carcinoma." in: Genes, chromosomes & cancer, Vol. 40, Issue 2, pp. 85-96, 2004 (PubMed).

West, Kapatos, OFarrell et al.: "N-myc regulates parkin expression." in: The Journal of biological chemistry, Vol. 279, Issue 28, pp. 28896-902, 2004 (PubMed).