|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated serine Esterase 1) (Gzmb) (N-Term) antibody
|Synonyms||HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1, GZB, CCP1, Ctla1, Ctla-1, AI553453, CCP-1/C11, RNKP-1, MGC156565, GZMB|
Alternatives Immunohistochemistry (IHC), Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10~39 amino acids from the N-terminal region of human GZMB.|
|Description||Other names: Granzyme B, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11, GRB, CTLA1, CSPB, CGL1, GZMB|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This GZMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10~39 amino acids from the N-terminal region of human GZMB.|
|Molecular Weight||27688 DA|
Background: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Immunohistochemistry ~~ 1:50~100 Flow cytometric~~1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Restrictions||For Research Use only|
Gaafar, Aljurf, Al-Sulaiman et al.: "Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients." in: Experimental hematology, Vol. 37, Issue 7, pp. 838-48, 2009 (PubMed).
Girnita, Webber, Brooks et al.: "Genotypic variation and phenotypic characterization of granzyme B gene polymorphisms." in: Transplantation, Vol. 87, Issue 12, pp. 1801-6, 2009 (PubMed).
Hagn, Schwesinger, Ebel et al.: "Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 3, pp. 1838-45, 2009 (PubMed).