Aurora Kinase C (AURKC) (AA 115-145), (Center) antibody

Details for Product No. ABIN390979
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Antigen
Epitope
AA 115-145, Center
(25), (9), (4), (3), (3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(63), (13), (13), (13), (13), (1), (1), (1)
Host
Rabbit
(54), (6), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(53), (30), (21), (12), (10), (4), (2), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN390979
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Immunogen This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 AA from the Central region of human Aurora-C.
Clone RB6822
Isotype Ig
Specificity This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human Aurora-C.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Aurora-C
Background Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Synonyms: Aurora/Ipl1/Eg2 protein 2, Serine/threonine protein kinase 13, Aurora/Ipl1-related kinase 3, Aurora-C
Molecular Weight 35591 DA
Gene ID 6795
UniProt Q9UQB9
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Aurora Kinase C (AURKC) (AA 115-145), (Center) antibody The anti-Aurora C Pab (ABIN390979) is used in Western blot to detect Aurora C in lysates of 293 cells expressing DYKDDDDK tag (lane 1), DYKDDDDK-tagged Aurora A (lane 2), DYKDDDDK-tagged Aurora B (lane 3), and DYKDDDDK-tagged Aurora C (lane 4). Data is kindly provided by Drs. K. Sasai and S. Sen from the University of Texas MD Anderson Cancer Center (Houston, TX).
anti-Aurora Kinase C (AURKC) (AA 115-145), (Center) antibody (2) Aurora-C Antibody (Ctr) (ABIN390979) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the Aurora-C antibody detected the Aurora-C protein (arrow).
Background publications Bernard, Sanseau, Henry et al.: "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." in: Genomics, Vol. 53, Issue 3, pp. 406-9, 1998 (PubMed).

Tseng, Chen, Hsu et al.: "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." in: DNA and cell biology, Vol. 17, Issue 10, pp. 823-33, 1998 (PubMed).

Kimura, Matsuda, Yoshioka et al.: "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7334-40, 1999 (PubMed).

General Burum-Auensen, Skotheim, Schjuolberg et al.: "Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors." in: Journal of carcinogenesis, Vol. 9, pp. 1, 2010 (PubMed).

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