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Aurora Kinase C antibody (AURKC) (AA 115-145)

Details for Product anti-AURKC Antibody No. ABIN390979, Supplier: Login to see
Antigen
  • AURKC
  • AIE2
  • AIK3
  • ARK3
  • AurC
  • SPGF5
  • STK13
  • aurora-C
  • AIE1
  • ARK-3
  • IAK3
  • Stk13
Alternatives
anti-Human Aurora Kinase C antibody for Western Blotting
Epitope
AA 115-145, Center
58
17
8
8
8
6
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
120
22
20
1
1
1
1
1
Host
Rabbit
93
14
13
Clonality (Clone)
Polyclonal ()
Conjugate
This Aurora Kinase C antibody is un-conjugated
8
8
8
7
7
7
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
103
62
30
19
11
10
7
3
Supplier
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Immunogen This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-145 AA from the Central region of human Aurora-C.
Clone RB6822
Isotype Ig
Specificity This Aurora-C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human Aurora-C.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Aurora-C (AURKC Antibody Abstract)
Background Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
Synonyms: Aurora/Ipl1/Eg2 protein 2, Serine/threonine protein kinase 13, Aurora/Ipl1-related kinase 3, Aurora-C
Molecular Weight 35591 DA
Gene ID 6795
UniProt Q9UQB9
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Signaling, Chromatin, Cell Structure
Pathways Cell Division Cycle
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Aurora Kinase C antibody (AURKC) (AA 115-145) (ABIN390979) The anti-Aurora C Pab (ABIN390979) is used in Western blot to detect Aurora C in lysa...
Western Blotting (WB) image for anti-Aurora Kinase C antibody (AURKC) (AA 115-145) (ABIN390979) Aurora-C Antibody (Ctr) (ABIN390979) western blot analysis in 293 cell line lysates (...
Product cited in: Burum-Auensen, Skotheim, Schjølberg et al.: "Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors." in: Journal of carcinogenesis, Vol. 9, pp. 1, 2010 (PubMed).

Background publications Kimura, Matsuda, Yoshioka et al.: "Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3." in: The Journal of biological chemistry, Vol. 274, Issue 11, pp. 7334-40, 1999 (PubMed).

Tseng, Chen, Hsu et al.: "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators." in: DNA and cell biology, Vol. 17, Issue 10, pp. 823-33, 1998 (PubMed).

Bernard, Sanseau, Henry et al.: "Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter." in: Genomics, Vol. 53, Issue 3, pp. 406-9, 1998 (PubMed).