|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Leucine-Rich Repeat Kinase 2 (LRRK2) (Leu955) antibody
|Synonyms||Gm927, cI-46, AW561911, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, PARK8, RIPK7, ROCO2, AURA17, DARDARIN, LRRK2|
Alternatives Immunofluorescence (IF), Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||PARK8 (LRRK2)|
|Immunogen||This PARK8 (LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide (10-30 aa in length) surrounding amino acid L955 of human LRRK2.|
|Description||Other names: Park8, Leucine-rich repeat (LRR) kinase 2, Leucine-rich repeat kinase 2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This PARK8 (LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide (10-30 aa in length) surrounding amino acid L955 of human LRRK2.|
|Molecular Weight||280863 DA|
Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure|
|Restrictions||For Research Use only|
Shen: "Protein kinases linked to the pathogenesis of Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 575-7, 2004 (PubMed).
Paisán-Ruíz, Jain, Evans et al.: "Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease." in: Neuron, Vol. 44, Issue 4, pp. 595-600, 2004 (PubMed).
Zimprich, Biskup, Leitner et al.: "Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology." in: Neuron, Vol. 44, Issue 4, pp. 601-7, 2004 (PubMed).