|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibody
|Synonyms||FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, ACTRIIB, ActR-IIB, MGC116908, ActRIIB, MGC118477, actr2b, actrIIb, wu:fj97d11, ACVR2B, Acvr2b, actriib, MGC89569, actr-iib|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.|
|Description||Other names: Activin receptor type 2B [Precursor], Activin receptor type IIB, ACTR-IIB, ACVR2B,|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.|
|Molecular Weight||57639 DA|
Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle|
|Restrictions||For Research Use only|
Shin, Wang, Yim et al.: "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7607-16, 2003 (PubMed).
Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).
Martins da Silva, Bayne, Cambray et al.: "Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation." in: Developmental biology, Vol. 266, Issue 2, pp. 334-45, 2004 (PubMed).
Harrison, Gray, Fischer et al.: "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28036-44, 2004 (PubMed).
|Hosts||Rabbit (23), Goat (5), Mouse (2)|
|Reactivities||Human (20), Mouse (Murine) (7), Rat (Rattus) (5), Cow (Bovine) (2), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1), Xenopus laevis (1), Zebrafish (1)|
|Applications||Western Blotting (WB) (30), ELISA (19), Immunohistochemistry (IHC) (9), Flow Cytometry (FACS) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Neutralization (Neut) (3), Dot Blot (DB) (1)|
|Epitopes||C-Term (4), Extracellular Domain (4), Center (2), Internal Region (2), N-Term (2), C-Term,Val474 (1), Internal Region,AA 147-176 (1)|