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Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibody

Details for Product No. ABIN391162, Supplier: Login to see
Antigen
  • ACVR2B
  • XAR1
  • actr-iib
  • actriib
  • ACTRIIB
  • ActR-IIB
  • HTX4
  • ActRIIB
  • actr2b
  • actrIIb
  • wu:fj97d11
Epitope
N-Term
22
15
13
10
5
5
5
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
92
36
25
4
2
2
1
1
1
1
Host
Rabbit
95
12
5
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
11
7
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
83
47
29
12
11
3
3
2
2
1
1
Supplier
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Immunogen This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.
Clone RB08166
Isotype Ig
Specificity This ACVR2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2B.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACVR2B (ACVR2B Antibody Abstract)
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor) displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Synonyms: Activin receptor type 2B [Precursor], Activin receptor type IIB, ACTR-IIB, ACVR2B,
Molecular Weight 57639 DA
Gene ID 93
UniProt Q13705
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibody (ABIN391162) Western blot analysis of ACVR2B N-term S14 (ABIN391162) in Jurkat cell line lysates (...
Western Blotting (WB) image for anti-Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibody (ABIN391162) Western blot analysis of anti-ACVR2B Antibody (N-term) (ABIN391162) in mouse heart, k...
Immunohistochemistry (IHC) image for anti-Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibody (ABIN391162) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: McKay, Ogborn, Bellamy et al.: "Myostatin is associated with age-related human muscle stem cell dysfunction." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 26, Issue 6, pp. 2509-21, 2012 (PubMed).

Background publications Harrison, Gray, Fischer et al.: "An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28036-44, 2004 (PubMed).

Martins da Silva, Bayne, Cambray et al.: "Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation." in: Developmental biology, Vol. 266, Issue 2, pp. 334-45, 2004 (PubMed).

Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).

Shin, Wang, Yim et al.: "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7607-16, 2003 (PubMed).