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Cyclin-Dependent Kinase-Like 5 (CDKL5) (AA 982-1012), (C-Term) antibody

Details for Product No. ABIN391362, Supplier: Log in to see
Antigen
  • issx
  • stk9
  • EIEE2
  • ISSX
  • STK9
  • BC038161
  • Stk9
Epitope
AA 982-1012, C-Term
36
15
14
14
13
7
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
59
36
16
2
2
2
2
2
Host
Rabbit
73
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
6
6
6
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
46
27
11
5
1
1
Supplier
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Immunogen This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 982-1012 AA from the C-terminal region of human CDKL5 (STK9).
Clone RB3556
Isotype Ig
Specificity This CDKL5 (STK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 990~1019 amino acids from the C-terminal region of human STK9.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDKL5 (STK9) (CDKL5 Antibody Abstract)
Background Defects in STK9, a dual-specificity serine/threonine kinase, are a cause of atypical Rett syndrome. Rett syndrome is an X-linked dominant disease. It is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Patients appear to develop normally until 6 to 18 months of age, then gradually lose speech and purposeful hand movements and develop microcephaly, seizures, autism, ataxia, intermittent hyperventilation, and stereotypic hand movements. After initial regression, the condition stabilizes and patients usually survive into adulthood. Rett syndrome due to CDKL5-associated mutations is characterized by a severe early-onset phenotype and atypical features such as infantile spasms.
Synonyms: Serine/threonine protein kinase 9, Cyclin-dependent kinase-like 5
Molecular Weight 115537 DA
Gene ID 6792
UniProt O76039
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase-Like 5 (CDKL5) (AA 982-1012), (C-Term) antibody (ABIN391362) The anti-STK9 Pab (ABIN391362) is used in Western blot to detect STK9 in mouse lung t...
Immunohistochemistry (IHC) image for anti-Cyclin-Dependent Kinase-Like 5 (CDKL5) (AA 982-1012), (C-Term) antibody (ABIN391362) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with STK9 An...
Background publications Montini, Andolfi, Caruso et al.: "Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region." in: Genomics, Vol. 51, Issue 3, pp. 427-33, 1998 (PubMed).