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Cyclin A2 (CCNA2) (C-Term), (AA 358-389) antibody

Details for Product No. ABIN391455
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Antigen
Epitope
C-Term, AA 358-389
(17), (11), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(117), (49), (37), (25), (4), (4), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(87), (55)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(113), (46), (35), (34), (30), (24), (15), (10), (6), (3), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN391455
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This CCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 AA from the C-terminal region of human CCNA2.
Clone RB14702
Isotype Ig
Specificity This CCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367~396 amino acids from the C-terminal region of human CCNA2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CCNA2
Background CCNA2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
Synonyms: Cyclin-A2, Cyclin-A, CCNA2, CCN1, CCNA
Molecular Weight 48537 DA
Gene ID 890
UniProt P20248
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin A2 (CCNA2) (C-Term), (AA 358-389) antibody Western blot analysis of CCNA2 (arrow) using rabbit polyclonal CCNA2 Antibody (C-term) (ABIN391455). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CCNA2 gene (Lane 2) (Origene Technologies).
anti-Cyclin A2 (CCNA2) (C-Term), (AA 358-389) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CCNA2 antibody (C-term) (ABIN391455), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Wang, Chenivesse, Henglein et al.: "Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma." in: Nature, Vol. 343, Issue 6258, pp. 555-7, 1990 (PubMed).

Henglein, Chenivesse, Wang et al.: "Structure and cell cycle-regulated transcription of the human cyclin A gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 12, pp. 5490-4, 1994 (PubMed).

Tsang, Wang, Chen et al.: "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression." in: The Journal of cell biology, Vol. 178, Issue 4, pp. 621-33, 2007 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391455
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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