You are viewing an incomplete version of our website. Please click to reload the website as full version.

MME antibody (Membrane Metallo-Endopeptidase) (AA 506-534)

Details for Product anti-MME Antibody No. ABIN391499, Supplier: Log in to see
Antigen
  • MME
  • NEP
  • CD10
  • CALLA
  • CAK
  • CD167
  • DDR
  • EDDR1
  • HGK2
  • MCK10
  • NTRK4
  • PTK3
  • PTK3A
  • RTK6
  • TRKE
  • AV378681
  • Mmel
  • 6030454K05Rik
  • C85356
  • SFE
  • Nep
Alternatives
anti-Human MME antibody for Immunoprecipitation
Epitope
AA 506-534, C-Term
32
19
19
16
14
12
6
6
6
6
6
5
5
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
457
62
61
2
1
1
Host
Rabbit
303
169
2
Clonality (Clone)
Polyclonal ()
Conjugate
This MME antibody is un-conjugated
53
42
31
23
6
5
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
213
195
118
111
76
59
51
47
26
13
12
8
5
4
3
2
2
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen This Neprilysin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 AA from the C-terminal region of human Neprilysin.
Clone RB18821
Isotype Ig
Specificity This Neprilysin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513~542 amino acids from the C-terminal region of human Neprilysin.
Predicted Reactivity Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Neprilysin (MME Antibody Abstract)
Background MME is a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a oprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Synonyms: Neprilysin, Neutral endopeptidase 24.11, Neutral endopeptidase, NEP, Enkephalinase, Atriopeptidase, Common acute lymphocytic leukemia antigen, CALLA, CD_antigen=CD10, EPN, MME
Molecular Weight 85514 DA
Gene ID 4311
UniProt P08473
Research Area Cell Structure
Pathways RTK Signaling
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MME antibody (Membrane Metallo-Endopeptidase) (AA 506-534) (ABIN391499) Western blot analysis of Neprilysin Antibody (C-term) (ABIN391499) in A2058,A375,Ramo...
Immunohistochemistry (IHC) image for anti-MME antibody (Membrane Metallo-Endopeptidase) (AA 506-534) (ABIN391499) Formalin-fixed and paraffin-embedded human kidney carcinoma with Neprilysin Antibody ...
Flow Cytometry (FACS) image for anti-MME antibody (Membrane Metallo-Endopeptidase) (AA 506-534) (ABIN391499) Neprilysin Antibody (C-term) (ABIN391499) flow cytometry analysis of Ramos cells (bot...
Background publications Dakka, Bellaoui, Bouzid et al.: "CD10 AND CD34 expression in childhood acute lymphoblastic leukemia in Morocco: clinical relevance and outcome." in: Pediatric hematology and oncology, Vol. 26, Issue 4, pp. 216-31, 2009 (PubMed).

Wang, Wang, Malter et al.: "Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells." in: Journal of neurochemistry, Vol. 108, Issue 4, pp. 1072-82, 2009 (PubMed).

Shipp, Vijayaraghavan, Schmidt et al.: "Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 1, pp. 297-301, 1989 (PubMed).

Shipp, Tarr, Chen et al.: "CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 23, pp. 10662-6, 1992 (PubMed).