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ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (AA 705-736), (C-Term) antibody

Details for Product No. ABIN391642, Supplier: Log in to see
Antigen
  • ADAMTS4
  • ADAMTS-4
  • DKFZp469J0817
  • ADAMTS13
  • ADAMTS5
  • ADAMTS-11
  • 3830423K05
  • ADAM-TS4
  • ADAMTS-2
  • ADMP-1
  • mKIAA0688
Epitope
AA 705-736, C-Term
39
13
13
12
8
8
6
5
4
3
3
3
3
3
1
1
1
1
Reactivity
Human, Mouse (Murine)
122
37
30
4
3
3
3
2
2
2
1
Host
Rabbit
110
20
4
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
8
6
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
80
36
29
23
16
11
4
3
3
1
1
1
Supplier
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Immunogen This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 705-736 AA from the C-terminal region of human ADAMTS4.
Clone RB18037
Isotype Ig
Specificity This ADAMTS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 713~743 amino acids from the C-terminal region of human ADAMTS4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADAMTS4 (ADAMTS4 Antibody Abstract)
Background ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Synonyms: ADMP-1, Aggrecanase-1, A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAMTS-4, ADAM-TS 4, ADAM-TS4, ADAMTS4, KIAA0688
Molecular Weight 90225 DA
Gene ID 9507
UniProt O75173
Research Area Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) (AA 705-736), (C-Term) antibody (ABIN391642) Western blot analysis of anti-ADAMTS4 Antibody (C-term) (ABIN391642) in mouse cerebel...
Product cited in: Lee, Lee, Gil et al.: "Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases." in: Archives of pathology & laboratory medicine, Vol. 138, Issue 5, pp. 643-50, 2014 (PubMed).

Background publications Tortorella, Pratta, Liu et al.: "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage." in: The Journal of biological chemistry, Vol. 275, Issue 33, pp. 25791-7, 2000 (PubMed).