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Homeodomain Interacting Protein Kinase 3 (HIPK3) (AA 1127-1156), (C-Term) antibody

Details for Product No. ABIN391779, Supplier: Log in to see
Antigen
  • ANPK
  • dyrk6
  • DYRK6
  • fist3
  • FIST3
  • HIPK3
  • MGC145460
  • pky
  • PKY
  • yak1
  • YAK1
Epitope
AA 1127-1156, C-Term
14
10
7
7
7
Reactivity
Human
55
18
18
5
2
2
1
Host
Rabbit
55
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
31
28
28
12
11
3
1
1
Supplier
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Immunogen This HIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1127-1156 AA from the C-terminal region of human HIPK3.
Clone RB3241
Isotype Ig
Specificity This HIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1134~1163 amino acids from the sequence of human HIPK3 within a 1100-1200.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HIPK3 (HIPK3 Antibody Abstract)
Background HIPK3 negatively regulates apoptosis by promoting FADD phosphorylation. This kinase enhances androgen receptor-mediated transcription, and may act as a transcriptional corepressor for NK homeodomain transcription factors.
Synonyms: Homeodomain-interacting protein kinase 3, Homolog of protein kinase YAK1, Fas-interacting serine/threonine-protein kinase, FIST, Androgen receptor-interacting nuclear protein kinase, ANPK, DYRK6, FIST3, PKY
Molecular Weight 133743 DA
Gene ID 10114
UniProt Q9H422
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling, Metabolism
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Homeodomain Interacting Protein Kinase 3 (HIPK3) (AA 1127-1156), (C-Term) antibody (ABIN391779) Detection of interaction between HIPK3 and SF-1 by coimmunoprecipitation. After expre...
Immunohistochemistry (IHC) image for anti-Homeodomain Interacting Protein Kinase 3 (HIPK3) (AA 1127-1156), (C-Term) antibody (ABIN391779) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Lan, Wu, Shih, Chung: "Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5910-6, 2012 (PubMed).

Tiefenbach, Moll, Nelson, Hu, Baev, Kislinger, Krause: "A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery." in: PLoS ONE, Vol. 5, Issue 3, pp. e9797, 2010 (PubMed).

Lan, Li, Lin, Lai, Chung: "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation." in: Molecular and cellular biology, Vol. 27, Issue 6, pp. 2027-36, 2007 (PubMed).

Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).