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Details for Product No. ABIN391943

Epidermal Growth Factor Receptor (EGFR) (AA 1048-1077), (Ser1070) antibody

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Antigen
Synonyms
ERBB, HER1, mENA, ERBB1, PIG61, 9030024J15Rik, AI552599, Erbb, Errb1, Errp, Wa5, wa-2, wa2, ErbB-1, c-erbB, C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top ... show more
Epitope
»Alternatives AA 1048-1077, Ser1070
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN391943
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1048-1077 AA from human EGFR.
Clone RB12736
Isotype Ig
Specificity This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S1070 of human EGFR.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EGFR
Background The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
Synonyms: Receptor protein-tyrosine kinase ErbB-1, EGFR
Molecular Weight 134277 DA
Gene ID 1956
UniProt P00533
Research Area Phospho-specific antibodies, Cell Signaling, Stem Cells, Protein Modifications, Cancer, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Huang, Jiang, Sorkin: "Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43411-7, 2003 (PubMed).

He, Huang, Gentry et al.: "Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42457-65, 2003 (PubMed).

Krug, Grossmann, Schuster et al.: "Aldosterone stimulates epidermal growth factor receptor expression." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43060-6, 2003 (PubMed).

Hirsch, Varella-Garcia, Bunn et al.: "Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 21, Issue 20, pp. 3798-807, 2003 (PubMed).

Zanardi, Yei, Lichtenstein et al.: "Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor." in: Journal of virology, Vol. 77, Issue 21, pp. 11685-96, 2003 (PubMed).

Alternatives for antigen "Epidermal Growth Factor Receptor (EGFR)", type "Antibodies"
Hosts (962), (246), (26), (15), (4), (1), (1)
Reactivities (1234), (645), (600), (164), (152), (125), (79), (7), (3), (2), (1)
Applications (795), (393), (303), (250), (189), (180), (121), (106), (76), (55), (25), (19), (15), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (62), (33), (27), (25), (25), (25), (25), (25), (25), (25), (25), (6), (2), (1), (1), (1), (1)
Epitopes (69), (47), (43), (42), (39), (38), (37), (37), (36), (31), (28), (22), (20), (19), (17), (17), (16), (15), (15), (13), (13), (13), (13), (13), (12), (12), (10), (10), (10), (9), (7), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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