EGFR antibody (Epidermal Growth Factor Receptor) (AA 1048-1077)

Details for Product anti-EGFR Antibody No. ABIN391943, Supplier: Log in to see
Antigen
  • C-erb
  • CG10079
  • D-EGFR
  • D-Egf
  • DEGFR
  • DER
  • DER flb
  • DER/EGFR
  • DER/faint little ball
  • DER/top
  • DER/torpedo
  • DER1
  • DEgfr
  • Degfr
  • Der
  • DmHD-33
  • Dmel\\CG10079
  • EFG-R
  • EGF-R
  • EGFR
  • EGFr
  • EGfr
  • EK2-6
  • Egf
  • Egf-r
  • EgfR
  • El
  • Elp
  • Elp-1
  • Elp-B1
  • Elp-B1RB1
  • HD-33
  • TOP
  • Torpedo/DER
  • Torpedo/Egfr
  • c-erbB
  • d-egf-r
  • dEGFR
  • dEGFR1
  • dEgfr
  • der
  • egfr
  • flb
  • l(2)05351
  • l(2)09261
  • l(2)57DEFa
  • l(2)57EFa
  • l(2)57Ea
  • mor1
  • top
  • top/DER
  • top/flb
  • torpedo/Egfr
  • torpedo/egfr
  • EGFR12
  • EGFR15
  • egfr1
  • Erbb2
  • ERBB
  • ERBB1
  • HER1
  • PIG61
  • mENA
  • ErbB-1
  • Errp
  • 9030024J15Rik
  • AI552599
  • Erbb
  • Errb1
  • Wa5
  • wa-2
  • wa2
  • epidermal growth factor receptor
  • Epidermal growth factor receptor
  • epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
  • EGFR
  • Egfr
  • egfra
  • egfr1
  • AaeL_AAEL004319
  • LOC100008806
Alternatives
anti-Mouse (Murine) EGFR antibody for Cytometry by Time of Flight
Epitope
AA 1048-1077, Ser1070
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48
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2
2
2
2
2
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2
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2
2
2
2
2
1
1
1
1
1
1
1
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1
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Reactivity
Human, Mouse (Murine)
2273
846
699
29
24
18
17
15
15
6
3
2
2
2
1
1
1
Host
Rabbit
1397
774
67
43
9
2
1
1
1
Clonality (Clone)
Polyclonal ()
Conjugate
This EGFR antibody is un-conjugated
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75
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2
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1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1324
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561
486
438
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109
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35
24
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11
8
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4
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2
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2
2
2
2
2
2
1
1
1
1
1
1
1
1
Options
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Immunogen This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1048-1077 AA from human EGFR.
Clone RB12736
Isotype Ig
Specificity This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S1070 of human EGFR.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EGFR (EGFR Antibody Abstract)
Background The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
Synonyms: Receptor protein-tyrosine kinase ErbB-1, EGFR
Molecular Weight 134277 DA
Gene ID 1956
UniProt P00533
Research Area Phospho-specific antibodies, Cell Signaling, Stem Cells, Protein Modifications, Cancer, Signaling, Cell Structure
Pathways NF-kappaB Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-EGFR antibody (Epidermal Growth Factor Receptor) (AA 1048-1077) (ABIN391943) Western blot analysis of anti-EGFR Antibody (S1070) (ABIN391943) in kidney heart tiss...
Western Blotting (WB) image for anti-EGFR antibody (Epidermal Growth Factor Receptor) (AA 1048-1077) (ABIN391943) Western blot analysis of EGFR (arrow) in Hela cell lysates, either induced (Lane 1) o...
Immunohistochemistry (IHC) image for anti-EGFR antibody (Epidermal Growth Factor Receptor) (AA 1048-1077) (ABIN391943) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with EGFR A...
Background publications Zanardi, Yei, Lichtenstein, Tollefson, Wold: "Distinct domains in the adenovirus E3 RIDalpha protein are required for degradation of Fas and the epidermal growth factor receptor." in: Journal of virology, Vol. 77, Issue 21, pp. 11685-96, 2003 (PubMed).

Krug, Grossmann, Schuster, Freudinger, Mildenberger, Govindan, Gekle: "Aldosterone stimulates epidermal growth factor receptor expression." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43060-6, 2003 (PubMed).

Huang, Jiang, Sorkin: "Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal growth factor receptor trafficking." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43411-7, 2003 (PubMed).

He, Huang, Gentry, Chignell: "Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 43, pp. 42457-65, 2003 (PubMed).

Hirsch, Varella-Garcia, Bunn, Di Maria, Veve, Bremmes, Barón, Zeng, Franklin: "Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 21, Issue 20, pp. 3798-807, 2003 (PubMed).