Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) antibody

Details for Product No. ABIN392016
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Antigen
Synonyms
CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, DDR, Dmel\\CG33531, Dmel_CG13984, 6030432F18, AI323681, CD167a, Cak, Nep, PTK3A, CAK, CD167, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, RTK6, TR ... show more
CG11573, CG13984, CG13985, CG33531, CG9488, CG9490, CT33540, DDR, Dmel\\CG33531, Dmel_CG13984, 6030432F18, AI323681, CD167a, Cak, Nep, PTK3A, CAK, CD167, EDDR1, HGK2, MCK10, NEP, NTRK4, PTK3, RTK6, TRKE, Drd1, PTK3D show less
Reactivity
Human
(111), (43), (42), (13), (12), (1)
Host
Rabbit
(97), (13), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(76), (58), (24), (21), (20), (7), (3), (1), (1)
Pubmed 3 references available
Quantity 400 μL
Options
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Catalog No. ABIN392016
291.50 $
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Immunogen This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein.
Clone RB14725
Isotype Ig
Specificity This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MCK10
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
Synonyms: discoidin receptor tyrosine kinase isoform a, PTK3A protein tyrosine kinase 3A, cell adhesion kinase, epithelial discoidin domain receptor 1, neurotrophic tyrosine kinase, receptor, type 4, neuroepithelial tyrosine kinase, mammarian carcinoma kinase 10
Molecular Weight 101127 DA
Gene ID 780
UniProt Q08345
Research Area Protein Modifications, Cancer, Cell Cycle, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) antibody Western blot analysis of anti-MCK10 Pab (ABIN392016) in SK-BR-3 cell line lysates (35 µg/lane).MCK10 (arrow) was detected using the purified polyclonal antibody (1:60 dilution).
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with MCK10 antibody (ABIN392016), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995 (PubMed).

Valent, Meddeb, Danglot et al.: "Assignment of the NTRK4 (trkE) gene to chromosome 6p21." in: Human genetics, Vol. 98, Issue 1, pp. 12-5, 1996 (PubMed).

Vogel, Gish, Alves et al.: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998 (PubMed).

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