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tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 934-964), (C-Term) antibody

Details for Product No. ABIN392083, Supplier: Log in to see
Antigen
  • ACK
  • ACK-1
  • ACK1
  • p21cdc42Hs
  • AW552477
  • Ack
  • Cdgip
  • Pyk1
Epitope
AA 934-964, C-Term
31
22
18
15
15
15
14
12
11
9
7
7
6
6
5
5
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
179
66
54
4
3
2
Host
Rabbit
178
2
1
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
12
10
10
9
8
8
3
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
96
41
36
23
18
17
8
7
6
5
2
1
Supplier
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Immunogen This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-964 AA from the C-terminal region of human ACK1.
Clone RB3101-3102
Isotype Ig
Specificity This ACK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 939~969 amino acids from the C-terminal region of human ACK1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ACK1 (TNK2 Antibody Abstract)
Background ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway.
Synonyms: Tyrosine kinase non-receptor protein 2, Activated CDC42 kinase 1, ACK-1, ACK1, TNK2
Molecular Weight 114327 DA
Gene ID 10188
UniProt Q07912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 934-964), (C-Term) antibody (ABIN392083) Western blot analysis of anti-ACK1 Antibody (C-term) (ABIN392083) in CEM cell line ly...
Western Blotting (WB) image for anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 934-964), (C-Term) antibody (ABIN392083) Western blot analysis of ACK1 (arrow) using rabbit polyclonal ACK1 Antibody (C-term) ...
Immunohistochemistry (IHC) image for anti-tyrosine Kinase, Non-Receptor, 2 (TNK2) (AA 934-964), (C-Term) antibody (ABIN392083) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Yokoyama, Miller: "Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47713-23, 2003 (PubMed).

Manser, Leung, Salihuddin et al.: "A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42." in: Nature, Vol. 363, Issue 6427, pp. 364-7, 1993 (PubMed).