TNK2 antibody (pTyr284)

Catalog No. ABIN6241018

Product Details anti-TNK2 Antibody

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Binding Specificity: pTyr284

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunogen: synthetic peptide

Application Details

Application Notes: IF: 1:100. WB: 1:1000. IHC: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for TNK2

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Alternative Name: ACK1 (TNK2 Products)

Synonyms: ACK antibody, ACK-1 antibody, ACK1 antibody, p21cdc42Hs antibody, AW552477 antibody, Ack antibody, Cdgip antibody, Pyk1 antibody, ack1 antibody, ackb antibody, tnk2 antibody, tnk2b antibody, wu:fj16g04 antibody, zgc:154019 antibody, tyrosine kinase non receptor 2 antibody, tyrosine kinase, non-receptor, 2 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK2 antibody, Tnk2 antibody, tnk1 antibody

Background: Non-receptor tyrosine-protein and serine/threonine- protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr- 287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

UniProt: Q07912