TNK2 antibody (pTyr284)

Catalog No. ABIN7138968

Product Details anti-TNK2 Antibody

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Binding Specificity: pTyr284

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunogen: Peptide sequence around phosphorylation site of tyrosine 284 (D-H-Y(p)-V-M) derived from Human ACK1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TNK2

Target: TNK2 (tyrosine Kinase, Non-Receptor, 2 (TNK2))

Alternative Name: TNK2 (TNK2 Products)

Synonyms: ACK antibody, ACK-1 antibody, ACK1 antibody, p21cdc42Hs antibody, AW552477 antibody, Ack antibody, Cdgip antibody, Pyk1 antibody, ack1 antibody, ackb antibody, tnk2 antibody, tnk2b antibody, wu:fj16g04 antibody, zgc:154019 antibody, tyrosine kinase non receptor 2 antibody, tyrosine kinase, non-receptor, 2 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK2 antibody, Tnk2 antibody, tnk1 antibody

Background:

Background:

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes.

Manser E., Nature 363:364-367(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Eisenmann K.M., Nat. Cell Biol. 1:507-513(1999)

Aliases: Acetate kinase 1 antibody, Acetokinase 1 antibody, ACK 1 antibody, ACK antibody, ACK-1 antibody, ACK1 antibody, ACK1_HUMAN antibody, Activated Cdc42 associated kinase 1 antibody, Activated CDC42 kinase 1 antibody, Activated p21cdc42Hs kinase antibody, FLJ44758 antibody, FLJ45547 antibody, p21cdc42Hs antibody, TNK 2 antibody, TNK2 antibody, Tyrosine kinase non receptor 2 antibody, Tyrosine kinase non receptor protein 2 antibody, Tyrosine kinase non-receptor protein 2 antibody

UniProt: Q07912