Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term), (AA 549-581) antibody

Details for Product No. ABIN392235
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Antigen
Epitope
C-Term, AA 549-581
(45), (11), (11), (7), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(112), (35), (15)
Host
Rabbit
(112), (13)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(116), (67), (24), (22), (18), (10), (9), (9), (6), (4)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN392235
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Immunogen This IRAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-581 AA from the C-terminal region of human IRAK2.
Clone RB2341
Isotype Ig
Specificity This IRAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 558~587 amino acids from the C-terminal region of human IRAK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IRAK2
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.
Synonyms: interleukin-1 receptor-associated kinase 2
Molecular Weight 65270 DA
Gene ID 3656
UniProt O43187
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term), (AA 549-581) antibody Western blot analysis of anti-IRAK2 Pab (ABIN392235) in K562 cell lysate. IRAK2 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term), (AA 549-581) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

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