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Details for Product No. ABIN392235

Interleukin-1 Receptor-Associated Kinase 2 (IRAK2) (C-Term), (AA 549-581) antibody

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Antigen
Synonyms IRAK-2, 6330415L08Rik, AI649099, irak-2
Epitope
»Alternatives C-Term, AA 549-581
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN392235
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This IRAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-581 AA from the C-terminal region of human IRAK2.
Clone RB2341
Isotype Ig
Specificity This IRAK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 558~587 amino acids from the C-terminal region of human IRAK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name IRAK2
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.
Synonyms: interleukin-1 receptor-associated kinase 2
Molecular Weight 65270 DA
Gene ID 3656
UniProt O43187
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Muzio, Ni, Feng et al.: "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling." in: Science (New York, N.Y.), Vol. 278, Issue 5343, pp. 1612-5, 1997 (PubMed).

Alternatives for antigen "Interleukin-1 Receptor-Associated Kinase 2 (IRAK2)", type "Antibodies"
Hosts (95), (14)
Reactivities (99), (34), (14)
Applications (100), (53), (23), (20), (16), (10), (4), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (35), (11), (8), (5), (2), (2), (1), (1), (1), (1), (1), (1)
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