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Kinase Suppressor of Ras 1 (KSR1) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN392257, Supplier: Login to see
Antigen
  • CG2899
  • Dmel\\CG2899
  • EK3-1
  • KSR
  • KSR-1
  • Ksr
  • Ksr-1
  • SR3-1
  • dKsr
  • l(3)j5E2
  • AW492498
  • B-KSR1
  • D11Bhm183e
  • D11Bhm184e
  • RSU2
  • hb
Epitope
AA 1-30, N-Term
38
18
16
13
7
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
83
47
23
Host
Rabbit
93
6
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
6
6
6
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
82
57
25
12
12
9
3
2
2
1
1
Supplier
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Immunogen This KSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human KSR1.
Clone RB3309
Isotype Ig
Specificity This KSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region with alanine at position 7 of human KSR1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KSR1 (KSR1 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
Synonyms: Kinase suppressor of ras-1
Molecular Weight 71671 DA
Gene ID 8844
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Transcription Factors, Signaling, Metabolism
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Kinase Suppressor of Ras 1 (KSR1) (AA 1-30), (N-Term) antibody (ABIN392257) Western blot analysis of anti-KSR1 Pab (ABIN392257) in A375 cell lysate. KSR1 (arrow)...
Immunohistochemistry (IHC) image for anti-Kinase Suppressor of Ras 1 (KSR1) (AA 1-30), (N-Term) antibody (ABIN392257) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Blume-Jensen, Hunter: "Oncogenic kinase signalling." in: Nature, Vol. 411, Issue 6835, pp. 355-65, 2001 (PubMed).