Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 489-518) antibody

Details for Product No. ABIN392275
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Antigen
Synonyms RIP3, Hcyp2, 2610528K09Rik, AW107945, Rip3, RIPK3
Epitope
C-Term, AA 489-518
(7), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(55), (31), (20), (15), (14), (12), (12), (3)
Host
Rabbit
(66), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(58), (24), (23), (10), (10), (6), (5), (3), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN392275
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-518 AA from the C-terminal region of human RIPK3.
Clone RB3319
Isotype Ig
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RIPK3
Background RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.

Synonyms: Receptor-interacting serine/threonine protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, RIP3
Molecular Weight 56901 Da
Gene ID 11035
NCBI Accession NP_006862
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC = 1:50-100
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 489-518) antibody Western blot analysis of hRIPK3-E504 (ABIN392275) in K562 cell line lysates (35 µg/lane). RIPK3 (arrow) was detected using the purified polyclonal antibody.
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 489-518) antibody (2) Western blot analysis of hRIPK3-E504 (ABIN392275) in mouse cerebellum tissue lysates (35 µg/lane). RIPK3 (arrow) was detected using the purified polyclonal antibody.
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 489-518) antibody (3) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with RIP3 (RIPK3) antibody (C-term) (ABIN392275), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Sun, Lee, Navas et al.: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999 (PubMed).

Hosts (66), (7)
Reactivities (55), (31), (20), (15), (14), (12), (12), (3)
Applications (58), (24), (23), (10), (10), (6), (5), (3), (1), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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