This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This CYP7A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-504 amino acids from the C-terminal region of human CYP7A1.
CP7A antibody, CYP7 antibody, CYPVII antibody, CHAP antibody, CYP7S1 antibody, cyp7a1a antibody, zgc:63920 antibody, cytochrome P450 family 7 subfamily A member 1 antibody, cytochrome P450, family 7, subfamily a, polypeptide 1 antibody, cytochrome P450, family 7, subfamily A, polypeptide 1 antibody, cholesterol 7-alpha-hydroxylase antibody, CYP7A1 antibody, Cyp7a1 antibody, cyp7a1 antibody
Background
CYP7A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body.