RPS6KB2 antibody (C-Term)

Catalog No. ABIN392546

There are 3+ publications for this product available. The Rabbit Polyclonal anti-RPS6KB2 antibody is suitable to detect RPS6KB2 in samples from Human. It has been validated for WB.

Quick Overview for RPS6KB2 antibody (C-Term) (ABIN392546)

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KB2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB0891

Product Details anti-RPS6KB2 Antibody

Binding Specificity: AA 452-482, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 amino acids from the C-terminal region of human p70 S6Kbeta.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-RPS6KB2 antibody (ABIN392546)

Wang, Li, Du, Xu, Wang, Zhang, Xu, Zeng, Mao, Cao: "The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex." in: Journal of pharmacological sciences, Vol. 134, Issue 4, pp. 197-202, (2018) (PubMed).

Kroczynska, Mehrotra, Majchrzak-Kita, Arslan, Altman, Stein, McMahon, Kozlowski, Kahle, Eklund, Fish, Platanias: "Regulatory effects of SKAR in interferon ? signaling and its role in the generation of type I IFN responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11377-82, (2014) (PubMed).

Cruz, Hedden, Boyer, Kharas, Fruman, Lee-Fruman: "S6 kinase 2 potentiates interleukin-3-driven cell proliferation." in: Journal of leukocyte biology, Vol. 78, Issue 6, pp. 1378-85, (2005) (PubMed).

Target Details for RPS6KB2

Target: RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2))

Alternative Name: p70 S6Kbeta

Background: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Molecular Weight: 53455

Gene ID: 6199

NCBI Accession: NP_003943

UniProt: Q9UBS0

Pathways: PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway