Protein Phosphatase 1D Magnesium-Dependent, delta Isoform (PPM1D) (C-Term) antibody

Antigen: Protein Phosphatase 1D Magnesium-Dependent, delta Isoform (PPM1D)

Synonyms: WIP1, PP2C-DELTA, Wip1, AV338790, MGC52997, MGC55836, zgc:55836, zgc:77316, wu:fj44c08, MGC80458, PPM1D

Epitope: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN392853

Additional Information

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Alternative name: PPM1D (C-term)

Swiss-Prot: O15297

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.

Isotype: Ig  (Matching secondary antibodies)

Description: Other names: Protein phosphatase 2C delta isoform, PP2C-delta, p53-induced protein phosphatase 1, Protein phosphatase magnesium-dependent 1 delta, WIP1

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human PPM1D.

Application Details

Application Notes: The suggested dilution will be: ELISA 1:1,000 Western blotting 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

The anti-PPM1D Pab (ABIN392853) is used in Western blot to detect PPM1D in 293 cell lysate.

Publications

Publications: Song, Han, Sabapathy et al.: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, 2010 (PubMed).

Moon, Lin, Zhang et al.: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, 2010 (PubMed).

Zhang, Wan, Mlotshwa et al.: "Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway." in: Cancer research, 2010 (PubMed).