PPM1D antibody (AA 1-250)

Catalog No. ABIN7165942

Product Details anti-PPM1D Antibody

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Binding Specificity: AA 1-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPM1D antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Rat

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein phosphatase 1D protein (1-250AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PPM1D

Target: PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))

Alternative Name: PPM1D (PPM1D Products)

Synonyms: PP2C-DELTA antibody, WIP1 antibody, AV338790 antibody, Wip1 antibody, zgc:103518 antibody, ppm1d antibody, wu:fj44c08 antibody, zgc:55836 antibody, zgc:77316 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D antibody, protein phosphatase 1D magnesium-dependent, delta isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1D antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antibody, PPM1D antibody, Ppm1d antibody, ppm1db antibody, ppm1d.L antibody, ppm1da antibody

Background:

Background: Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates \\\'Ser-15\\\' of TP53 and \\\'Ser-345\\\' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629).

Aliases: EC 3.1.3.16 antibody, p53 induced protein phosphatase 1 antibody, p53-induced protein phosphatase 1 antibody, PP2C delta antibody, PP2C-delta antibody, PP2CD antibody, Ppm1d antibody, PPM1D_HUMAN antibody, Protein phosphatase 1D antibody, protein phosphatase 1D magnesium-dependent delta isoform antibody, Protein phosphatase 2C delta isoform antibody, Protein phosphatase 2C isoform delta antibody, Protein phosphatase magnesium dependent 1 delta antibody, Protein phosphatase magnesium-dependent 1 delta antibody, Protein phosphatase Mg2+/Mn2+ dependent 1D antibody, Protein phosphatase Wip1 antibody, Wild type p53 induced phosphatase 1 antibody, WIP 1 antibody, WIP1 antibody

UniProt: O15297

Pathways: p53 Signaling, Cell Division Cycle