FOXO1 antibody (AA 242-655)

Catalog No. ABIN400650

The Mouse Monoclonal anti-FOXO1 antibody (Clone 7h3) (ABIN400650) specifically detects FOXO1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for FOXO1 antibody (AA 242-655) (ABIN400650)

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 7h3

Product Details anti-FOXO1 Antibody

Binding Specificity: AA 242-655

Specificity: This antibody recognizes Human FKHR.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Characteristics: Synonyms: Forkhead Box Protein O1, FOXO1, FKHR, Forkhead Box Protein O1A, Forkhead inRhabdomyosarcoma

Purification: Protein G Chromatography.

Immunogen: Fusion protein containing the region encoding aa 242-655 of Human FOXO1A expressed inE. coli.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 0.1-2.0 μg/mL. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing no preservatives.

Preservative: Without preservative

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for FOXO1

Target: FOXO1 (Forkhead Box O1 (FOXO1))

Alternative Name: FOXO1A

Background: FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined, however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2), also known as alveolar rhabdomyosarcoma.Synonyms: FKHR, FOXO1, Forkhead Box Protein O1, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma

Gene ID: 2308

UniProt: Q12778

Pathways: PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling