THRB antibody (Isoform 1, Isoform beta-1, N-Term)

Catalog No. ABIN401449

This Rabbit Polyclonal antibody specifically detects THRB in WB, IP and EIA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for THRB antibody (Isoform 1, Isoform beta-1, N-Term) (ABIN401449)

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Product Details anti-THRB Antibody

Binding Specificity: Isoform 1, Isoform beta-1, N-Term

Specificity: This antibody reacts with THRB protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity chromatography

Immunogen: Synthetic peptide corresponding to a region near the N-terminal of human THRB isoform 1 protein

Isotype: IgG

Application Details

Application Notes: ELISA: 1/200,000 - 1/220,000. Western Blot: 1/500 - 1/2,000. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.66 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB / ERBA2

Background: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, THR1, Thyroid hormone receptor beta

Gene ID: 7068

NCBI Accession: NP_000452

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound