Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term), (pSer732) antibody

Details for Product No. ABIN401474
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Antigen
Synonyms RSK, HU-1, RSK1, MAPKAPK1A, rsk, Rsk1, p90rsk, hu-1, mapkapk1a, rsk1
Epitope
C-Term, pSer732
(25), (22), (20), (20), (16), (7), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Chicken, Horse (Equine), Human, Mouse (Murine), Opossum (Didelphimorphia), Rat (Rattus)
(180), (82), (73), (43), (41), (36), (26), (4), (1)
Host
Rabbit
(168), (22)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
ELISA, Western Blotting (WB)
(144), (71), (44), (40), (26), (23), (18), (14), (6), (2), (2), (2)
Pubmed 1 reference available
Catalog no. ABIN401474
Quantity 25 µL
Price
291.50 $   Plus shipping costs $45.00
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Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to a region near the C-terminal end of human RSK1 protein
Isotype IgG
Specificity This antibody is specific for p90 RSK1 protein phosphorylated at S732.
Purification Affinity chromatography
Alternative Name RPS6KA1
Background Ribosomal S6 Kinase 1 (RSK1, S6K-alpha 1, 90 kDa Ribosomal Protein S6 Kinase 1, MAP kinase-activated protein kinase 1a, or MAPKAPK1A) is an immediate downstream effector of mitogen activated protein kinases and therefore promotes cell proliferation and survival. It has serine/threonine kinase activity and may play a role in mediating the growth-factor and stress-induced activation of the transcription factor CREB. The C-terminal region of RSK1 is reported to be an ERK docking site, where serine 732 phosphorylation status is critical for RSK1 activation. When serine 732 is not phosphorylated, ERK1/2 binds to the ERK docking site of RSK1, and upon stimulation, activates RSK1. The activated RSK1 then autophosphorylates serine 732, leading to the dissociation of ERK from RSK1 and termination of activation by ERK.
Alternate names: 90 kDa ribosomal protein S6 kinase 1, MAPKAPK1A, RSK-1, RSK1, Ribosomal S6 kinase 1, Ribosomal protein S6 kinase alpha-1, p90RSK1
Gene ID 6195
NCBI Accession NP_001006666.1
UniProt Q15418
Research Area Signaling
Application Notes ELISA: 1/100,000. Western Blot: 1/500 - 1/2,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.64 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01% (w/v) Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term), (pSer732) antibody anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (C-Term), (pSer732) antibody
Background publications Chaturvedi, Poppleton, Stringfield et al.: "Subcellular localization and biological actions of activated RSK1 are determined by its interactions with subunits of cyclic AMP-dependent protein kinase." in: Molecular and cellular biology, Vol. 26, Issue 12, pp. 4586-600, 2006 (PubMed).

Hosts (168), (22)
Reactivities (180), (82), (73), (43), (41), (36), (26), (4), (1)
Applications (144), (71), (44), (40), (26), (23), (18), (14), (6), (2), (2), (2)
Conjugates (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (25), (22), (20), (20), (16), (7), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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