Eyes Absent Homolog 1 (Drosophila) (EYA1) (Middle Region) antibody

Details for Product No. ABIN404801
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Antigen
Synonyms EYA1, bop, bor, XEya1, wu:fc13c10, zgc:100770, BOP, BOR, BOS1
Epitope
Middle Region
(10), (10), (6), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio), Human
(25), (23), (14), (13), (13), (12), (12)
Host
Rabbit
(28), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(23), (11), (10), (4)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN404801
289.00 $
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Immunogen Synthetic peptide directed towards the middle region of human EYA1
Sequence QDYPSYPSFG QGQYAQYYNS SPYPAHYMTS SNTSPTTPST NATYQLQEPP
Predicted Reactivity Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, African clawed frog : 90 %, Bovine : 90 %, Chicken : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against EYA1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name EYA1
Background EYA1 is a member of the eyes absent (EYA) family of proteins. EYA1 may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator.This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Four transcript variants encoding three distinct isoforms have been identified for this gene.
Molecular Weight 61 kDa
Gene ID 2138
NCBI Accession NP_742057, NM_172060
UniProt Q99502
Research Area Organogenesis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 557 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Eyes Absent Homolog 1 (Drosophila) (EYA1) (Middle Region) antibody anti-Eyes Absent Homolog 1 (Drosophila) (EYA1) (Middle Region) antibody
Background publications Orten, Fischer, Sorensen et al.: "Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR." in: Human mutation, Vol. 29, Issue 4, pp. 537-44, 2008 (PubMed).

Validation Images
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