CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) (Middle Region) antibody

Details for Product No. ABIN404993
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Antigen
Synonyms CHRNA7, CHRNA7-DR1, D-10
Epitope
Middle Region
(4), (2), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Pig (Porcine), Zebrafish (Danio rerio), Human, Chicken
(16), (3), (3), (2), (2), (2), (1), (1)
Host
Rabbit
(15), (3), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(17), (4), (3), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN404993
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen Synthetic peptide directed towards the middle region of human CHRFAM7A
Sequence QRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPT PDSGVVCGRM
Predicted Reactivity Mouse :100 %,   Human :100 %,   Rhesus macaque :100 %,   Rat :100 %,   Bovine :90 %,   Pig :90 %,   Herring gull :90 %,   Common quail :90 %,   Chicken :90 %,   Zebrafish :90 %,  
Characteristics This is a rabbit polyclonal antibody against CHRFAM7A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CHRFAM7A
Background The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7 is located on chromosome 15 in a region associated with several neuropsychiatric disorders. CHRFAM7A is is a hybrid between CHRNA7 and FAM7A. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.
Molecular Weight 35 kDa
Gene ID 89832
NCBI Accession NM_148911, NP_683709
UniProt Q8IUZ4
Research Area Neurology
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 321 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) (Middle Region) antibody WB Suggested Anti-CHRFAM7A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 293T cell lysate
Background publications Martin, Leonard, Hall et al.: "Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 144B, Issue 5, pp. 611-4, 2007 (PubMed).

Hosts (15), (3), (1)
Reactivities (16), (3), (3), (2), (2), (2), (1), (1)
Applications (17), (4), (3), (1), (1)
Epitopes (4), (2), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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