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Homeobox B8 (HOXB8) (Middle Region) antibody

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Antigen
Synonyms Hox2r1a, HOX2, HOX2D, Hox-2.4
Epitope
Middle Region
(35), (18), (15), (4), (3), (2), (2), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine)
(56), (25), (16), (1), (1), (1)
Host
Rabbit
(58), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (37), (11), (3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human HOXB8
Blocking Peptide Blocking peptide for this product available: ABIN978179
Sequence FQNRRMKWKK ENNKDKFPSS KCEQEELEKQ KLERAPEAAD EGDAQKGDKK
Predicted Reactivity Dog : 100 %, Human : 100 %, Pig : 100 %, Mouse : 70 %, Rat : 70 %
Characteristics This is a rabbit polyclonal antibody against HOXB8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name HOXB8 (HOXB8 Antibody Abstract)
Background HOXB8 belongs to the Antp homeobox family. It is a nuclear protein with a homeobox DNA-binding domain. This gene is included in a cluster of homeobox B genes located on chromosome 17. The protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Molecular Weight 27 kDa
Gene ID 3218
NCBI Accession NM_024016, NP_076921
UniProt P17481
Research Area Embryogenesis, Embryonic stem cells, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 243 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Homeobox B8 (HOXB8) (Middle Region) antibody (ABIN405048) anti-Homeobox B8 (HOXB8) (Middle Region) antibody
Background publications Kosaki, Kosaki, Suzuki et al.: "Complete mutation analysis panel of the 39 human HOX genes." in: Teratology, Vol. 65, Issue 2, pp. 50-62, 2002 (PubMed).

Catalog No. ABIN405048
$289.00
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