Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4) (Middle Region) antibody

Details for Product No. ABIN405577
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Antigen
Synonyms ADH-2, ADH-1, Ac1002, Adh2
Epitope
Middle Region
(9), (8), (5), (4), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(33), (6), (4), (1)
Host
Rabbit
(24), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(33), (14), (12), (9), (4), (4), (2), (1)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN405577
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Immunogen Synthetic peptide directed towards the middle region of human ADH4
Sequence PLTNLCGKIS NLKSPASDQQ LMEDKTSRFT CKGKPVYHFF GTSTFSQYTV
Predicted Reactivity Human : 100 %
Characteristics This is a rabbit polyclonal antibody against ADH4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ADH4
Background ADH4, class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
Molecular Weight 40 kDa
Gene ID 127
NCBI Accession NM_000670, NP_000661
UniProt P08319
Research Area Signaling, Metabolism
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 380 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4) (Middle Region) antibody anti-Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4) (Middle Region) antibody
anti-Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4) (Middle Region) antibody (2) anti-Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4) (Middle Region) antibody (Image 2)
Product cited in: Kuo, Yu, Petrovich et al.: "The CyberKnife stereotactic radiosurgery system: description, installation, and an initial evaluation of use and functionality." in: Neurosurgery, Vol. 62 Suppl 2, pp. 785-9, 2008 (PubMed).

Background publications Kuo, Kalsi, Prescott et al.: "Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample." in: Alcoholism, clinical and experimental research, Vol. 32, Issue 5, pp. 785-95, 2008 (PubMed).

Validation Images
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