PABP antibody (Middle Region)

Catalog No. ABIN453247

Product Details anti-PABP Antibody

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PABP antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to PABPC1.

Purification: Saturated Ammonium Sulfate (SAS) precipitation

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human PABPC1

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PABP

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Alternative Name: PABPC1 (PABPC1 Products)

Synonyms: PAB1 antibody, PABP antibody, PABP1 antibody, PABPC2 antibody, PABPL1 antibody, Pabp1 antibody, PabpI antibody, Pabpl1 antibody, ePAB antibody, Pabp antibody, pab1 antibody, pabp antibody, pabp1 antibody, pabpc1 antibody, pabpc2 antibody, PABPC1 antibody, wu:fb16a02 antibody, wu:fi19b08 antibody, wu:fj12d09 antibody, wu:fj61f06 antibody, zgc:109879 antibody, zgc:77608 antibody, poly(A) binding protein cytoplasmic 1 antibody, poly(A) binding protein, cytoplasmic 1 antibody, poly(A) binding protein, cytoplasmic 1 S homeolog antibody, poly(A) binding protein cytoplasmic 1 like antibody, poly(A) binding protein, cytoplasmic 1 L homeolog antibody, poly(A) binding protein, cytoplasmic 1a antibody, poly A binding protein, cytoplasmic 1 b antibody, PABPC1 antibody, Pabpc1 antibody, pabpc1.S antibody, pabpc1 antibody, PABPC1L antibody, pabpc1.L antibody, pabpc1a antibody, pabpc1b antibody

Background: PABPC1 binds the poly(A) tail of mRNA. It may be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. PABPC1 can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. It may be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.Synonyms: PAB1, PABP-1, PABP1, PABPC2, Poly(A)-binding protein 1, Polyadenylate-binding protein 1

Gene ID: 26986

NCBI Accession: NP_002559

UniProt: P11940

Pathways: SARS-CoV-2 Protein Interactome