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UCHL1 antibody (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase)) (C-Term)

Details for Product anti-UCHL1 Antibody No. ABIN453450, Supplier: Log in to see
Antigen
  • AW822034
  • C88048
  • cb358
  • gad
  • MGC132191
  • park5
  • PARK5
  • PGP9.5
  • PGP 9.5
  • pgp9.5
  • PGP95
  • R75593
  • uch-l1
  • UCH-L1
  • Uch-L1
  • UCHL-1
  • UCHL1
  • uchl1
  • wu:fc55h08
Epitope
C-Term
52
30
24
22
14
13
11
11
9
8
7
6
6
5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
487
240
219
111
107
68
56
47
47
47
8
7
3
3
1
Host
Rabbit
257
200
34
17
6
4
Clonality
Polyclonal
Conjugate
This UCHL1 antibody is un-conjugated
19
18
16
14
10
10
9
9
9
9
9
7
7
7
7
7
7
7
7
3
2
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
413
228
176
126
104
69
65
13
12
9
5
5
3
3
Supplier
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Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human UCHL1
Specificity This antibody reacts to UCHL1 / PGP9.5.
Purification Affinity chromatography on Protein A
Alternative Name UCHL1 / PGP9.5 (UCHL1 Antibody Abstract)
Background UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1
Gene ID 7345
NCBI Accession NP_004172
UniProt P09936
Research Area Tags/Labels, Cell/Tissue Markers
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-UCHL1 antibody (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase)) (C-Term) (ABIN453450) (LEFT) Western blot analysis of UCHL1 Antibody (C-term) in Ramos, NCI-H460 cell line ...
Background publications Maraganore, de Andrade, Lesnick, Farrer, Bower, Hardy, Rocca: "Complex interactions in Parkinson's disease: a two-phased approach." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 18, Issue 6, pp. 631-6, 2003 (PubMed).

Nishikawa, Li, Kawamura, Osaka, Wang, Hara, Hirokawa, Manago, Amano, Noda, Aoki, Wada: "Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants." in: Biochemical and biophysical research communications, Vol. 304, Issue 1, pp. 176-83, 2003 (PubMed).

Liu, Fallon, Lashuel, Liu, Lansbury: "The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility." in: Cell, Vol. 111, Issue 2, pp. 209-18, 2002 (PubMed).

Caballero, Resto, Patturajan, Meerzaman, Guo, Engles, Yochem, Ratovitski, Sidransky, Jen: "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)." in: Oncogene, Vol. 21, Issue 19, pp. 3003-10, 2002 (PubMed).

Saigoh, Wang, Suh, Yamanishi, Sakai, Kiyosawa, Harada, Ichihara, Wakana, Kikuchi, Wada: "Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice." in: Nature genetics, Vol. 23, Issue 1, pp. 47-51, 1999 (PubMed).