anti-Retinoblastoma 1 antibody (RB1) (C-Term)

Details for Product anti-RB1 Antibody No. ABIN453807, Supplier: Login to see New
New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms RB1, OSRC, RB, p105-Rb, pRb, pp110, Rb, Rb-1, zgc:154147, P105-RB, PP110, RB11
Alternatives
Epitope
C-Term
(55), (53), (50), (42), (35), (28), (26), (21), (17), (17), (16), (13), (9), (9), (8), (8), (7), (7), (7), (7), (6), (6), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(540), (267), (243), (11), (8), (7), (5), (5), (4), (4), (3), (3), (2), (2)
Host
Rabbit
(480), (69), (3)
Clonality
Polyclonal
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
(22), (20), (20), (15), (13), (13), (10), (9), (9), (7), (7), (7), (7), (7), (7)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(336), (220), (183), (83), (82), (76), (44), (35), (16), (13), (10), (7), (6), (5), (2), (2), (2), (1), (1)
Pubmed 2 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.4 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen KLH conjugated synthetic peptide selected from the C-terminal region of human RB1
Specificity This antibody reacts to RB1.
Purification Saturated Ammonium Sulfate (SAS) precipitation
Alternative Name Retinoblastoma-Associated Protein / RB1 (RB1 Antibody Abstract)
Background RB1 is a negative regulator of the cell cycle and was the first tumor suppressor gene found. This protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
NCBI Accession NP_000312
UniProt P06400
Pathways Cell Division Cycle
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium az
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Retinoblastoma 1 antibody (RB1) (C-Term) (ABIN453807) Western blot analysis of RB1 Antibody
Background publications Connell-Crowley, Harper, Goodrich: "Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation." in: Molecular biology of the cell, Vol. 8, Issue 2, pp. 287-301, 1997 (PubMed).

Kitagawa, Higashi, Jung et al.: "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2." in: The EMBO journal, Vol. 15, Issue 24, pp. 7060-9, 1997 (PubMed).

Catalog No. ABIN453807
$401.50
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)