anti-WNT5A antibody (Wingless-Type MMTV Integration Site Family, Member 5A) (Middle Region)

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Antigen
Synonyms WNT5A, 8030457G12Rik, Wnt-5a, wnt-5A, wnt5a-B, hWNT5A
Alternatives
Epitope
Middle Region
(15), (14), (13), (10), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Xenopus laevis
(87), (35), (23), (13), (1)
Host
Rabbit
(67), (31), (1), (1)
Clonality
Polyclonal
Conjugate
This WNT5A antibody is un-conjugated
(6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(77), (52), (49), (19), (15), (11), (10), (4), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human WNT5A
Blocking Peptide Blocking peptide for this product available: Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) (Middle Region) peptide (ABIN986222)
Sequence GGCGDNIDYG YRFAKEFVDA RERERIHAKG SYESARILMN LHNNEAGRRT
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Rat : 100 %, African clawed frog : 90 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against WNT5A. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name WNT5A (WNT5A Antibody Abstract)
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT5A is a member of the WNT protein family. It shows 98 %, 98 % and 88 % amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98 %, 98 % and 88 % amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.
Molecular Weight 42 kDa
Gene ID 7474
NCBI Accession NP_003383, NM_003392
UniProt P41221
Pathways WNT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 380 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-WNT5A antibody (Wingless-Type MMTV Integration Site Family, Member 5A) (Middle Region) (ABIN486904) anti-Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) (Middle Region) antibody
Immunohistochemistry (IHC) image for anti-WNT5A antibody (Wingless-Type MMTV Integration Site Family, Member 5A) (Middle Region) (ABIN486904) anti-Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) (Middle Region) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-WNT5A antibody (Wingless-Type MMTV Integration Site Family, Member 5A) (Middle Region) (ABIN486904) anti-Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A) (Middle Region) antibody (Image 3)
Background publications Witze, Litman, Argast et al.: "Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors." in: Science (New York, N.Y.), Vol. 320, Issue 5874, pp. 365-9, 2008 (PubMed).

Catalog No. ABIN486904
$289.00
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