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DcR1 antibody (N-Term) (PE)
TNFRSF10C
Reactivity: Human
FACS
Host: Mouse
Monoclonal
TRAIL-R3-02
PE
Product Details anti-DcR1 Antibody (PE)
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Target
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DcR1 (TNFRSF10C)
(Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
Binding Specificity
All epitopes for DcR1 antibodies
AA 1-280, N-Term
Reactivity
All reactivities for DcR1 antibodies
Human
Host
All hosts for DcR1 antibodies
Mouse
Clonality
All clonalities for DcR1 antibodies
Monoclonal
Conjugate
All conjugates for DcR1 antibodies
This DcR1 antibody is conjugated to PE
Application
All applications for DcR1 antibodies
Flow Cytometry (FACS)
Specificity
The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Characteristics
Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3, Tumor necrosisfactor receptor superfamily member 10C, Decoy TRAIL receptor without death domain,TNF-related apoptosis-inducing ligand receptor 3, Trail receptor without an intracellulardomain, Lymphocyte inhibitor of TRAIL, Antagonist decoy receptor for TRAIL/Apo-2L
Purification
Size-Exclusion Chromatography.
Immunogen
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
Clone
TRAIL-R3-02
Isotype
IgG1
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Application Details
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Application Notes
Flow Cytometry: 3 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
0.1 mg/mL
Buffer
PBS containing 15 mM Sodium Azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody in the dark at 2-8 °C. DO NOT FREEZE! Avoid prolonged exposure to light. Shelf life: one year from despatch.
Expiry Date
12 months
Target Details for DcR1
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Target
DcR1 (TNFRSF10C)
(Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
Alternative Name
CD263 / TRAILR3 (TNFRSF10C Products )
Synonyms
CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody
Background
TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L, DCR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, LIT, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRID, Trail receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C
Gene ID
8794
UniProt
O14798
Pathways
Apoptosis
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