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MGP antibody (AA 20-96)

MGP Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN4886666
  • Target See all MGP Antibodies
    MGP (Matrix Gla Protein (MGP))
    Binding Specificity
    • 6
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-96
    Reactivity
    • 22
    • 18
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 33
    • 5
    • 1
    • 1
    Rabbit
    Clonality
    • 37
    • 3
    Polyclonal
    Conjugate
    • 20
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MGP antibody is un-conjugated
    Application
    • 28
    • 20
    • 10
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Matrix Gla protein(MGP) detection. Tested with WB, IHC-P in Human.
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Matrix Gla protein(MGP) detection. Tested with WB, IHC-P in Human.
    Gene Name: matrix Gla protein
    Protein Name: Matrix Gla protein
    Purification
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human MGP recombinant protein (Position: Y20-F96). Human MGP shares 84.4% and 80.5% amino acid (aa) sequence identity with mouse and rat MGP, respectively.
    Isotype
    IgG
    Top Product
    Discover our top product MGP Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    MGP (Matrix Gla Protein (MGP))
    Alternative Name
    MGP (MGP Products)
    Synonyms
    MGLAP antibody, NTI antibody, Mglap antibody, mgp-A antibody, MGP antibody, LOC100136434 antibody, mgp antibody, matrix Gla protein antibody, matrix Gla protein L homeolog antibody, MGP antibody, Mgp antibody, mgp.L antibody, mgp antibody
    Background
    Matrix Gla protein (MGP) is an 84-residue vitamin K-dependent protein initially isolated from bovine bone. In addition, MGP is a 10-kD protein produced and secreted by vascular smooth muscle cells and chondrocytes and significantly accumulated in bone, cartilage, and dentin. It is also expressed at high levels in heart, kidney, and lung and is upregulated by vitamin D in bone cells. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. And this gene is mapped to 12p12.3.

    Synonyms: GIG36 | Matrix Gla protein | MGLAP | MGP | NTI | P08493
    Gene ID
    4256
    UniProt
    P08493
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