OAZ1 antibody

Catalog No. ABIN4904605

Product Details anti-OAZ1 Antibody

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAZ1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Characteristics: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Purification: Affinity purification

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Alternative Name: OAZ1 (OAZ1 Products)

Synonyms: AZI antibody, OAZ antibody, AZ-1 antibody, AZ1 antibody, Antizyme antibody, ODC-Az antibody, Oaz antibody, ODCAC antibody, oaz antibody, AZS antibody, oaz1 antibody, ornithine decarboxylase antizyme 1 antibody, ornithine decarboxylase antizyme 1 S homeolog antibody, ornithine decarboxylase antizyme 1a antibody, OAZ1 antibody, Oaz1 antibody, oaz1.S antibody, oaz1a antibody

Gene ID: 4946

UniProt: P54368