OAZ1 antibody (AA 14-63)

Catalog No. ABIN1535135

The Rabbit Polyclonal anti-OAZ1 antibody (ABIN1535135) specifically detects OAZ1 in IHC, WB, ELISA and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for OAZ1 antibody (AA 14-63) (ABIN1535135)

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAZ1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-OAZ1 Antibody

Binding Specificity: AA 14-63

Purpose: AZ1 Antibody

Specificity: AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Purity: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63

Isotype: IgG

Application Details

Application Notes: IHC 1:100 - 1:300. ELISA: 1:40000,WB 1:500-2000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Alternative Name: OAZ1

Background:

Synonyms: OAZ1, OAZ, Ornithine decarboxylase antizyme 1, ODC-Az

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit.This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms

Gene Name: OAZ1

Protein Name: Ornithine decarboxylase antizyme 1

Molecular Weight: 25 kDa

Gene ID: 4946

OMIM: 601579

UniProt: P54368