OAZ1 antibody (AA 1-68)

Catalog No. ABIN6144987

This Rabbit Polyclonal antibody specifically detects OAZ1 in WB. It exhibits reactivity toward Human.

Quick Overview for OAZ1 antibody (AA 1-68) (ABIN6144987)

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAZ1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-OAZ1 Antibody

Binding Specificity: AA 1-68

Sequence: MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS RVSLHCCSNP GPGPRWCS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human OAZ1 (NP_004143.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for OAZ1

Target: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Alternative Name: OAZ1

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.,OAZ1,AZ1,AZI,OAZ,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Endocrine & Metabolism,Amino acid metabolism,OAZ1

Molecular Weight: 25 kDa

Gene ID: 4946

UniProt: P54368