BRCA1 antibody (pSer988)

Catalog No. ABIN540547

Product Details anti-BRCA1 Antibody

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Binding Specificity: pSer988

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Immunofluorescence (IF)

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.

Sequence: IKSpFV

Specificity: BRCA1 (phospho-Ser988) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 988.

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S988 of human BRCA1.

Application Details

Application Notes: Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In PBS (without Mg²⁺ and Ca²⁺), 150 mM NaCl, pH 7.4 (50 % glycerol, 0.02 % sodium azide)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-BRCA1 antibody (ABIN540547)

Okada, Ouchi: "Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 2015-20, (2003) (PubMed).

Tutt, Ashworth: "The relationship between the roles of BRCA genes in DNA repair and cancer predisposition." in: Trends in molecular medicine, Vol. 8, Issue 12, pp. 571-6, (2002) (PubMed).

Scully, Livingston: "In search of the tumour-suppressor functions of BRCA1 and BRCA2." in: Nature, Vol. 408, Issue 6811, pp. 429-32, (2000) (PubMed).

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1 / RNF53 (BRCA1 Products)

Synonyms: BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody

Gene ID: 672

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus