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APP antibody (Amyloid beta (A4) Precursor Protein) (N-Term)

Details for Product anti-APP Antibody No. ABIN499321, Supplier: Log in to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human APP antibody for Enzyme Immunoassay
Epitope
N-Term
117
107
51
35
25
18
17
17
15
15
14
14
14
13
12
11
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8
8
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3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
802
306
276
40
11
11
8
8
6
3
2
2
1
1
1
1
Host
Rabbit
565
217
46
4
2
Clonality
Polyclonal
Conjugate
This APP antibody is un-conjugated
48
37
35
17
13
13
13
13
13
13
13
12
12
11
11
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
542
311
228
146
131
74
52
26
23
18
14
10
9
8
6
3
2
2
2
2
1
Supplier
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Immunogen APP antibody was raised against an 18 amino acid peptide near the amino terminus of human APP.
Isotype IgG
Specificity This antibody reacts to APP.
Purification Affinity chromatography purified via peptide column
Alternative Name Amyloid beta A4 Protein / APP (APP Antibody Abstract)
Background Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimers disease patients' brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the Beta-amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimers disease.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gene ID 1238255
UniProt P05067
Research Area Neurology, Alzheimer's Disease
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes ELISA. Western Blot: APP antibody can be used for detection of APP at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-APP antibody (Amyloid beta (A4) Precursor Protein) (N-Term) (ABIN499321) Immunohistochemistry of APP in mouse brain tissue with APP antibody at 2.5 μg/ml.
Western Blotting (WB) image for anti-APP antibody (Amyloid beta (A4) Precursor Protein) (N-Term) (ABIN499321) Western blot analysis of APP in rat brain tissue lysate with AP30073PU-N APP antibody...
Product cited in: Nikolaev, McLaughlin, OLeary et al.: "APP binds DR6 to trigger axon pruning and neuron death via distinct caspases." in: Nature, Vol. 457, Issue 7232, pp. 981-9, 2009 (PubMed).

Background publications Ponte, Gonzalez-DeWhitt, Schilling et al.: "A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors." in: Nature, Vol. 331, Issue 6156, pp. 525-7, 1988 (PubMed).