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CARD11 antibody (Caspase Recruitment Domain Family, Member 11)

Details for Product anti-CARD11 Antibody No. ABIN499539, Supplier: Login to see New
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Synonyms CARD11, LOC100232755, BENTA, BIMP3, CARMA1, PPBL, 0610008L17Rik, 2410011D02Rik
Human, Mouse (Murine)
(72), (28), (5), (4), (4), (1), (1)
(54), (20), (1), (1)
This CARD11 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(69), (39), (34), (17), (7), (6), (4), (3), (2), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human CARMA1 Peptide
Isotype IgG
Specificity CARMA1 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARMA1.
Purification Affinity chromatography purified via peptide column
Alternative Name CARD11 / CARMA1 (CARD11 Antibody Abstract)
Background CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (1). CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types (2-4). Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the I?K complex, thereby regulating activation of the NF-kappaB transcription factor (5). Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems (6).Synonyms: CARD-containing MAGUK protein 3, Caspase recruitment domain-containing protein 11
Gene ID 84433
UniProt Q9BXL7
Research Area Apoptosis/Necrosis
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes ELISA. Western Blot: CARMA1 antibody can be used for detection of CARMA1 at 0.5 to 2 μg/mL. Aband at approximately 125 kDa can be detected. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-CARD11 antibody (Caspase Recruitment Domain Family, Member 11) (ABIN499539) Immunohistochemistry of CARMA1 in mouse thymus with CARMA1 antibody at 10 μg/ml.
Western Blotting (WB) image for anti-CARD11 antibody (Caspase Recruitment Domain Family, Member 11) (ABIN499539) Western blot analysis of CARMA1 expression in mouse thymus cell lysate with AP30186PU...
Background publications McAllister-Lucas, Inohara, Lucas et al.: "Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 30589-97, 2001 (PubMed).

Gaide, Martinon, Micheau et al.: "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation." in: FEBS letters, Vol. 496, Issue 2-3, pp. 121-7, 2001 (PubMed).

Bertin, Wang, Guo et al.: "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 15, pp. 11877-82, 2001 (PubMed).

Fanning, Anderson: "Protein modules as organizers of membrane structure." in: Current opinion in cell biology, Vol. 11, Issue 4, pp. 432-9, 1999 (PubMed).

Catalog No. ABIN499539
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