DACT2
Reactivity: Human, Mouse, Rat
ELISA, WB, IHC (p), IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C.
Tan, Li, Huang, Cheng, Zhao, Chen, Chen, Tang, Zhang, Huang, Cheng: "Upregulation of DACT2 suppresses proliferation and enhances apoptosis of glioma cell via inactivation of YAP signaling pathway." in: Cell death & disease, Vol. 8, Issue 8, pp. e2981, (2018) (PubMed).
Zhao, Herman, Brock, Sheng, Zhang, Liu, Guo: "Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling." in: PLoS ONE, Vol. 9, Issue 11, pp. e112336, (2015) (PubMed).
Target
DACT2
(Dapper, Antagonist of beta-Catenin 2 (DACT2))
The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.Synonyms: C6orf116, DAPPER2, DPR2, PP13671, dapper homolog 2