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IL27 antibody (Interleukin 27) (Center)

Details for Product anti-IL27 Antibody No. ABIN500002, Supplier: Log in to see
Antigen
  • IL-17D
  • IL-22
  • IL-27
  • IL-27A
  • IL-27p28
  • IL27
  • IL27A
  • IL27p28
  • Il30
  • IL30
  • p28
  • RGD1561420
Epitope
Center
22
17
17
14
13
12
12
7
6
5
4
3
3
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
88
62
11
1
1
Host
Rabbit
98
30
17
3
Clonality
Polyclonal
Conjugate
This IL27 antibody is un-conjugated
10
8
8
7
6
5
3
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
106
62
22
19
9
6
5
4
4
3
3
2
1
1
1
1
1
1
1
Supplier
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Immunogen IL-27 antibody was raised against a 14 amino acid peptide from near the center of human IL-27.
Isotype IgG
Specificity This antibody reacts to IL-27.
Purification Affinity chromatography purified via peptide column
Alternative Name Interleukin-27 / IL27A (IL27 Antibody Abstract)
Background Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-γ, and T-bet.Synonyms: IL-27 subunit alpha, IL-30, IL27-A, IL30, Interleukin-30, p28
Gene ID 246778
NCBI Accession NP_663634
UniProt Q8NEV9
Application Notes ELISA. Western Blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Western Blotting (WB) image for anti-IL27 antibody (Interleukin 27) (Center) (ABIN500002) Western blot analysis of IL-27 in Daudi lysate with AP30421PU-N IL-27 antibody at (A)...
Background publications Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells." in: Immunity, Vol. 16, Issue 6, pp. 779-90, 2002 (PubMed).