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DHX58 antibody (DEXH (Asp-Glu-X-His) Box Polypeptide 58) (C-Term)

Details for Product anti-DHX58 Antibody No. ABIN500164, Supplier: Log in to see
Antigen
  • MGC82787
  • DHX58
  • lgp2
  • D11LGP2
  • D11lgp2e
  • LGP2
  • RLR-3
  • B430001I08Rik
  • D11Lgp2e
  • LPG2
  • Lgp2
  • RGD1310093
Epitope
C-Term
30
22
15
7
4
4
3
2
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
91
24
24
2
1
1
1
Host
Rabbit
72
15
4
Clonality
Polyclonal
Conjugate
This DHX58 antibody is un-conjugated
3
3
3
3
3
3
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
85
55
21
6
5
4
Supplier
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Immunogen LGP2 antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human LGP2.
Isotype IgG
Specificity This antibody detects DHX58 at C-term.
Purification Peptide affinity chromatography
Alternative Name DHX58 (DHX58 Antibody Abstract)
Background Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.Synonyms: ATP-dependent RNA helicase DHX58, ATP-dependent helicase LGP2, D11LGP2E, DHX58, LGP2, Protein D11Lgp2 homolog
Gene ID 79132
UniProt Q96C10
Research Area Immunology, DNA/RNA
Application Notes ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-DHX58 antibody (DEXH (Asp-Glu-X-His) Box Polypeptide 58) (C-Term) (ABIN500164) Western blot analysis of LGP2 in rat kidney tissue lysate with this product at (A) 1 ...
Background publications Akira, Uematsu, Takeuchi: "Pathogen recognition and innate immunity." in: Cell, Vol. 124, Issue 4, pp. 783-801, 2006 (PubMed).

Andrejeva, Childs, Young et al.: "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 49, pp. 17264-9, 2004 (PubMed).

Iwasaki, Medzhitov: "Toll-like receptor control of the adaptive immune responses." in: Nature immunology, Vol. 5, Issue 10, pp. 987-95, 2004 (PubMed).

Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Benesh, Liyanage: "Surface-embedded Green-function method for general surfaces: Application to Al(111)." in: Physical review. B, Condensed matter, Vol. 49, Issue 24, pp. 17264-17272, 1999 (PubMed).