LRFN5
Reactivity: Mammalian
IHC, ISt
Host: Mouse
Monoclonal
N140A-12
unconjugated
Application Notes
ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target
LRFN5
(Leucine Rich Repeat and Fibronectin Type III Domain Containing 5 (LRFN5))
C14orf146 antibody, FIGLER8 antibody, SALM5 antibody, AI427653 antibody, AI604817 antibody, C130061B21 antibody, mKIAA4208 antibody, leucine rich repeat and fibronectin type III domain containing 5 antibody, LRFN5 antibody, Lrfn5 antibody
Background
LRFN5 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while LRFN2 and LRFN5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN5 are known to exist. This antibody is predicted to not cross-react with other members of the LRFN family.Synonyms: C14orf146, Leucine-rich repeat and fibronectin type-III domain-containing protein 5, SALM5