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NGFR antibody (Nerve Growth Factor Receptor)

Details for Product anti-NGFR Antibody No. ABIN500337, Supplier: Log in to see
Antigen
  • ngfr
  • wu:fb38c02
  • wu:fc10h01
  • CD271
  • Gp80-LNGFR
  • TNFRSF16
  • p75(NTR)
  • p75NTR
  • LNGFR
  • RNNGFRR
  • Tnfrsf16
  • p75
  • NRH1b
  • fullback
  • nrh1
  • p75ntr
  • tnfrsf16
  • p75NGFR
Alternatives
anti-Human NGFR antibody for Flow Cytometry
Reactivity
Human, Mouse (Murine)
244
93
81
19
17
15
14
12
9
8
6
5
2
1
1
1
1
1
Host
Rabbit
129
109
32
4
1
Clonality
Polyclonal
Conjugate
This NGFR antibody is un-conjugated
15
15
13
12
5
4
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
186
106
79
78
61
41
34
30
14
13
11
7
6
4
4
2
1
1
Supplier
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Immunogen NGFR antibody was raised against purified recombinant human NGFR.
Isotype IgG
Specificity This antibody detects CD271 / NGFR.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Peptide affinity chromatography
Alternative Name CD271 / NGFR (NGFR Antibody Abstract)
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Gene ID 4804
NCBI Accession NP_002498
UniProt P08138
Research Area Growth Factors, Receptors
Pathways NF-kappaB Signaling, Neurotrophin Signaling Pathway
Application Notes ELISA. Western blot: 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-NGFR antibody (Nerve Growth Factor Receptor) (ABIN500337) Immunocytochemistry of NGFR in A20 cells with AP30590PU-N antibody at 10 μg/ml.
Western Blotting (WB) image for anti-NGFR antibody (Nerve Growth Factor Receptor) (ABIN500337) Western blot analysis of (A) 25 ng, (B) 50 ng, and (C) 100 ng of purified recombinant...
Background publications Gentry, Barker, Carter: "The p75 neurotrophin receptor: multiple interactors and numerous functions." in: Progress in brain research, Vol. 146, pp. 25-39, 2003 (PubMed).

Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).