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Nerve Growth Factor Receptor (NGFR) antibody

Details for Product No. ABIN500337
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Antigen
Synonyms CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, ngfr, wu:fb38c02, wu:fc10h01, NRH1b, fullback, nrh1, p75ntr, tnfrsf16
Reactivity
Human, Mouse (Murine)
(148), (79), (71), (34), (14), (13), (13), (6), (5), (4), (3), (2), (2), (1), (1)
Host
Rabbit
(112), (48), (10), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(120), (62), (42), (40), (34), (32), (30), (24), (20), (18), (4), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN500337
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen NGFR antibody was raised against purified recombinant human NGFR.
Isotype IgG
Specificity This antibody detects CD271 / NGFR. Species Reactivity: Tested: Human, mouse
Purification Peptide affinity chromatography
Alternative Name CD271 / NGFR
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen- activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).
Alternate names: TNFRSF16, Tumor necrosis factor receptor superfamily member 16
Gene ID 4804
NCBI Accession NP_002498
UniProt P08138
Research Area Growth Factors, Receptors
Application Notes ELISA. Western blot: 1 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Johnson, Lanahan, Buck et al.: "Expression and structure of the human NGF receptor." in: Cell, Vol. 47, Issue 4, pp. 545-54, 1986 (PubMed).

Gaur, Aggarwal: "Regulation of proliferation, survival and apoptosis by members of the TNF superfamily." in: Biochemical pharmacology, Vol. 66, Issue 8, pp. 1403-8, 2003 (PubMed).

Gentry, Barker, Carter: "The p75 neurotrophin receptor: multiple interactors and numerous functions." in: Progress in brain research, Vol. 146, pp. 25-39, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN500337
401.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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