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PERP antibody (TP53 Apoptosis Effector) (C-Term)

Details for Product anti-PERP Antibody No. ABIN500475, Supplier: Log in to see
Antigen
  • PERP
  • PERPL
  • kcp1
  • krtcap1
  • pigpc1
  • thw
  • fk24g11
  • wu:fk24g11
  • LOC100221212
  • 1110017A08Rik
  • KCP1
  • KRTCAP1
  • PIGPC1
  • THW
  • RP3-496H19.1
  • dJ496H19.1
Epitope
C-Term
42
15
5
3
2
2
1
1
Reactivity
Human
63
5
4
4
2
2
1
Host
Rabbit
48
15
Clonality
Polyclonal
Conjugate
This PERP antibody is un-conjugated
3
3
3
3
3
3
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
56
34
20
8
7
2
1
1
Supplier
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Immunogen PERP antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP, which differ from the mouse sequence by three amino acids (7-9).
Isotype IgG
Specificity This antibody detects PERP.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification DEAE purified
Alternative Name PERP (PERP Antibody Abstract)
Background The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6), MTBP (7) and PERP (8), were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein (8-10). p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis (8). The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family (8).Synonyms: KCP-1, KCP1, KRTCAP1, Keratinocyte-associated protein 1, P53-induced protein PIGPC1, PERP, PIGPC1, THW, Transmembrane protein THW, p53 apoptosis effector related to PMP-22
Gene ID 64058
UniProt Q9JK95
Research Area Signaling, Extracellular Matrix, Apoptosis/Necrosis
Application Notes ELISA. Western blot. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-PERP antibody (TP53 Apoptosis Effector) (C-Term) (ABIN500475) Immunocytochemistry of PERP in A431 cells with this product at 10 μg/ml.
Western Blotting (WB) image for anti-PERP antibody (TP53 Apoptosis Effector) (C-Term) (ABIN500475) Western blot analysis of PERP expression in A431 whole cell lysates in the absence (A...
Background publications Oda, Arakawa, Tanaka et al.: "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53." in: Cell, Vol. 102, Issue 6, pp. 849-62, 2000 (PubMed).

Oda, Ohki, Murasawa et al.: "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis." in: Science (New York, N.Y.), Vol. 288, Issue 5468, pp. 1053-8, 2000 (PubMed).

Tanaka, Arakawa, Yamaguchi et al.: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." in: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000 (PubMed).

Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).