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PICALM antibody (N-Term)
PICALM
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PICALM Antibody
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Target
See all PICALM Antibodies
PICALM
(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
Binding Specificity
All epitopes for PICALM antibodies
N-Term
Reactivity
All reactivities for PICALM antibodies
Human, Mouse, Rat
Host
All hosts for PICALM antibodies
Rabbit
Clonality
All clonalities for PICALM antibodies
Polyclonal
Conjugate
All conjugates for PICALM antibodies
This PICALM antibody is un-conjugated
Application
All applications for PICALM antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Peptide affinity chromatography
Immunogen
PICALM antibody was raised against a 15 amino acid peptide from near the amino terminus of human PICALM.
Isotype
IgG
Top Product
Discover our top product PICALM Primary Antibody
Alternatives
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anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (AA 438-487) antibody
PICALM
Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Bat, Monkey, Pig
WB
Host: Rabbit
Polyclonal
unconjugated
anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (AA 277-326) antibody
PICALM
Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Bat, Monkey, Pig, Chicken
WB
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
ELISA. Western blot: 1 - 2 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at -20 °C.
Target Details for PICALM
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Target
PICALM
(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
Alternative Name
PICALM (PICALM Products )
Synonyms
LAP-3 antibody, PEPS antibody, CALM antibody, CLTH antibody, LAP antibody, PAP180 antibody, fit-1 antibody, fit1 antibody, mKIAA4114 antibody, Calm antibody, leucine aminopeptidase 3 antibody, phosphatidylinositol binding clathrin assembly protein antibody, si:ch211-200p22.4 antibody, LAP3 antibody, PICALM antibody, Picalm antibody, si:ch211-200p22.4 antibody
Background
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).Synonyms: CALM, Clathrin assembly lymphoid myeloid leukemia protein, Phosphatidylinositol-binding clathrin assembly protein
Gene ID
8301
NCBI Accession
NP_009097
UniProt
Q13492
Pathways
Synaptic Membrane
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